Quick Overview
High-purity Semax, a synthetic heptapeptide analog derived from the adrenocorticotropic hormone (ACTH 4-10) fragment, synthesized specifically for in vitro laboratory research and development. Formulated as a sterile, lyophilized powder to ensure maximum stability and precision in neurobiological and cognitive research models.
Product Description
Semax is a synthetic peptide consisting of the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro, acting as an analog of the ACTH (4-10) fragment coupled with a tripeptide Pro-Gly-Pro tail for enhanced metabolic stability. Designed without systemic endocrine activity, it has been extensively utilized in scientific research focusing on neuroprotection, brain-derived neurotrophic factor (BDNF) modulation, and cognitive function pathways. In vitro, Semax serves as a valuable tool for investigating cerebral cellular survival mechanisms, signal transduction cascades, and neurotransmitter regulation under induced stress models.
Common Research Applications:
- Neuroprotection Studies: Investigating cellular survival pathways and protection against oxidative and ischemic stress models.
- BDNF & Neurotrophin Modulation: Observing transcriptional regulation of brain-derived neurotrophic factors and related receptor expression.
- Synaptic Plasticity & Signaling: Analyzing receptor binding kinetics, signal transduction, and neurotransmitter modulation.
- Enzymatic Stability: Assessing the structural advantages of the Pro-Gly-Pro C-terminal extension against rapid peptide degradation.
Technical Specifications
| Compound Name | Semax |
|---|---|
| CAS Number | 80714-61-0 |
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | 723.82 g/mol |
| Peptide Sequence | Met-Glu-His-Phe-Pro-Gly-Pro (7 Amino Acids) |
| Purity (HPLC) | ≥98.0% |
| Appearance | White lyophilized solid |
| Solubility | Soluble in sterile water or bacteriostatic water |
Storage and Reconstitution
To maintain peptide integrity and stability, please adhere to standard laboratory handling guidelines:
- Lyophilized Form (Dry Powder): Store desiccated at -20°C (or below) upon receipt. While stable at room temperature for brief transit periods, long-term freezing is required to prevent degradation.
- Reconstitution: Reconstitute using bacteriostatic water or sterile water for injection. Introduce the diluent carefully and gently swirl the vial until dissolved. Do not shake vigorously, as this can fracture the peptide bonds.
- Liquid Storage (Reconstituted): Once reconstituted, the solution should be stored at 2°C to 8°C (refrigerated) and utilized within 14 to 30 days. For extended experimental timelines, aliquot the solution into individual vials and freeze at -20°C to avoid repeated freeze-thaw cycles.
Regulatory & Safety Disclaimer
NOTICE TO BUYER: By purchasing this product, you legally acknowledge and agree that it is strictly for Research Use Only (RUO). It is unequivocally prohibited to be used as a drug, food additive, cosmetic, or household chemical.
- Not for Human or Animal Use: This material has not been evaluated or approved by the FDA (or any other international regulatory agency) for therapeutic, diagnostic, or clinical use.
- Qualified Personnel: This product must be handled exclusively by qualified scientific professionals in a regulated laboratory setting, utilizing standard safety and sterile protocols.
- Liability: The purchaser assumes all risks and liabilities associated with the handling, storage, and experimental application of this product.
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