Quick Overview

High-purity KPV (Lysine-Proline-Valine), a biologically active tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone ($\alpha$-MSH), synthesized specifically for in vitro laboratory research and development. Formulated as a sterile, lyophilized powder to ensure maximum stability and precision in immunological and anti-inflammatory assay models.

Product Description

KPV is a potent, low-molecular-weight tripeptide composed of the amino acids Lysine, Proline, and Valine. Representing the active carboxy-terminal fragment of alpha-MSH, KPV exhibits powerful anti-inflammatory and immunomodulatory properties without triggering the systemic melanotropic effects associated with larger hormone chains. In vitro, KPV is heavily utilized by scientific professionals to study mucosal barrier integrity, inflammatory cytokine down-regulation, and cellular immune response pathways.

Common Research Applications:

• Anti-Inflammatory Studies: Investigating the down-regulation of pro-inflammatory cytokines and nuclear factor kappa B (NF-$\kappa$B) pathways.
• Mucosal Barrier Models: Observing epithelial cellular repair dynamics and barrier function integrity in culture assays.
• Immunomodulation Research: Assessing leukocyte activity, macrophage responses, and localized immune signaling.
• Enzymatic Stability: Analyzing the pharmacokinetic advantages and cellular uptake mechanisms of compact tripeptide sequences.

Technical Specifications

Storage and Reconstitution

To maintain peptide integrity and stability, please adhere to standard laboratory handling guidelines:

• Lyophilized Form (Dry Powder): Store desiccated at -20°C (or below) upon receipt. While stable at room temperature for brief transit periods, long-term freezing is required to prevent degradation.
• Reconstitution: Reconstitute using bacteriostatic water or sterile water for injection. Introduce the diluent carefully and gently swirl the vial until dissolved. Do not shake vigorously, as this can fracture the peptide bonds.
• Liquid Storage (Reconstituted): Once reconstituted, the solution should be stored at 2°C to 8°C (refrigerated) and utilized within 14 to 30 days. For extended experimental timelines, aliquot the solution into individual vials and freeze at -20°C to avoid repeated freeze-thaw cycles.

Regulatory & Safety Disclaimer