Quick Overview
High-purity Retatrutide (LY3437943), a novel triple-agonist peptide targeting the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R), synthesized specifically for in vitro laboratory research and development. Formulated as a sterile, lyophilized powder to ensure maximum stability and precision in advanced metabolic, receptor binding, and cellular signaling assays.
Product Description
Retatrutide is a synthetic 39-amino-acid peptide engineered as a single-molecule triple hormone receptor agonist. By simultaneously activating GCGR, GIPR, and GLP-1R, it coordinates multi-pathway metabolic regulation, including energy expenditure modulation, insulinotropic signaling, and appetite-related cellular mechanisms. In vitro models utilize Retatrutide to investigate complex synergistic receptor kinetics, thermogenic pathways, and energy metabolism homeostasis.
Common Research Applications:
- Triple Receptor Kinetics: Investigating simultaneous GCGR, GIPR, and GLP-1R binding affinities and coordinated intracellular activation pathways.
- Metabolic & Energy Expenditure Studies: Observing cellular lipid metabolism, hepatic fat oxidation models, and thermogenic signaling dynamics.
- Insulinotropic Pathway Analysis: Assessing glucose-dependent insulin secretion mechanisms and beta-cell responses in culture assays.
- Assay Optimization: Evaluating prolonged peptide stability, degradation resistance, and multi-agonist receptor desensitization profiles.
Technical Specifications
| Compound Name | Retatrutide (LY3437943) |
|---|---|
| CAS Number | 2381089-83-2 |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | 4731.34 g/mol |
| Peptide Sequence | 39 Amino Acids (Triple GCGR/GIPR/GLP-1R Agonist) |
| Purity (HPLC) | ≥98.0% |
| Appearance | White lyophilized solid |
| Solubility | Slightly soluble in water or dilute aqueous buffers |
Storage and Reconstitution
To maintain peptide integrity and stability, please adhere to standard laboratory handling guidelines:
- Lyophilized Form (Dry Powder): Store desiccated at -20°C (or below) upon receipt. While stable at room temperature for brief transit periods, long-term freezing is required to prevent degradation.
- Reconstitution: Reconstitute using bacteriostatic water or sterile water for injection. Introduce the diluent carefully and gently swirl the vial until dissolved. Do not shake vigorously, as this can fracture the peptide bonds.
- Liquid Storage (Reconstituted): Once reconstituted, the solution should be stored at 2°C to 8°C (refrigerated) and utilized within 14 to 30 days. For extended experimental timelines, aliquot the solution into individual vials and freeze at -20°C to avoid repeated freeze-thaw cycles.
Regulatory & Safety Disclaimer
NOTICE TO BUYER: By purchasing this product, you legally acknowledge and agree that it is strictly for Research Use Only (RUO). It is unequivocally prohibited to be used as a drug, food additive, cosmetic, or household chemical.
- Not for Human or Animal Use: This material has not been evaluated or approved by the FDA (or any other international regulatory agency) for therapeutic, diagnostic, or clinical use.
- Qualified Personnel: This product must be handled exclusively by qualified scientific professionals in a regulated laboratory setting, utilizing standard safety and sterile protocols.
- Liability: The purchaser assumes all risks and liabilities associated with the handling, storage, and experimental application of this product.
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