Quick Overview

High-purity SLU-PP-332 (commonly known as SLU332), a potent pan-estrogen-related receptor (ERR) agonist synthesized specifically for in vitro laboratory research and development. Formulated as a highly stable research compound, it is extensively utilized to study metabolic pathways, mitochondrial function, and exercise-mimetic gene expression.

Product Description

SLU-PP-332 is a potent and selective pan-agonist for estrogen-related receptors (ERRα, ERRβ, and ERRγ). Note: While frequently categorized alongside research peptides in laboratory catalogs, SLU-PP-332 is structurally a synthetic small molecule, not an amino acid chain.

Unlike traditional compounds, it directly targets nuclear transcription factors to activate gene programs central to oxidative phosphorylation, fatty acid oxidation, and mitochondrial biogenesis. In vitro and preclinical models have demonstrated its unique ability to induce an acute “exercise-like” transcriptional response. This makes it an incredibly valuable tool for scientific professionals studying metabolic syndrome, cellular energy expenditure, and lipid homeostasis without the variable of physical exertion.

Common Research Applications:

• Metabolic Studies: Investigating the cellular up-regulation of fatty acid oxidation and basal energy expenditure.
• Exercise-Mimetic Pathways: Observing ERR-dependent transcriptional responses and mitochondrial biogenesis in skeletal muscle cell lines.
• Obesity & Lipid Homeostasis: Analyzing the compound’s effects on adipocyte size, insulin sensitivity, and lipid accumulation in metabolic syndrome models.
• Cardiac & Muscle Energetics: Studying the role of ERR agonism in cellular respiration and tissue-specific oxidative metabolism.

Technical Specifications

Storage and Reconstitution

To maintain compound integrity and stability, please adhere to standard laboratory handling guidelines:

• Dry Powder Form: Store desiccated at -20°C (or below) upon receipt. It is highly stable in dry form when kept frozen and protected from light.
• Reconstitution: Because SLU-PP-332 is a lipophilic small molecule rather than a water-soluble peptide, it typically requires an organic solvent such as DMSO for reconstitution. Introduce the solvent carefully and swirl gently until completely dissolved.
• Liquid Storage (Reconstituted): Once reconstituted in DMSO, the stock solution should be aliquoted into individual vials to avoid repeated freeze-thaw cycles and stored tightly sealed at -20°C. For extended experimental timelines, utilize reconstituted solutions within 3 to 6 months.

Regulatory & Safety Disclaimer