Quick Overview
High-purity CJC-1295 with DAC (Drug Affinity Complex), a synthetic growth hormone-releasing hormone (GHRH) analog modified for extended half-life, synthesized specifically for in vitro laboratory research and development. Formulated as a sterile, lyophilized powder to ensure maximum stability and precision in endocrine, receptor binding, and metabolic research models.
Product Description
CJC-1295 with DAC is a modified 29-amino-acid peptide analog of human growth hormone-releasing hormone (GHRH) featuring a Drug Affinity Complex (DAC) covalent attachment. This structural modification allows the peptide to bind reversibly to serum albumin, protecting it from rapid enzymatic degradation and substantially extending its biological half-life in vivo and in vitro. In scientific research, CJC-1295 with DAC serves as an essential tool for examining prolonged GHRH receptor activation, pituitary stimulation kinetics, and sustained downstream metabolic pathways.
Common Research Applications:
- Extended Half-Life Studies: Investigating albumin-binding pharmacokinetics and enzymatic protection mechanisms provided by the DAC modification.
- GHRH Receptor Kinetics: Assessing long-term receptor binding affinity and downstream cellular signaling cascades.
- Endocrine Pathway Analysis: Observing sustained growth hormone secretagogue responses and regulatory feedback dynamics.
- Assay Optimization: Analyzing prolonged peptide stability and structural persistence in specialized experimental culture environments.
Technical Specifications
| Compound Name | CJC-1295 with DAC (Drug Affinity Complex) |
|---|---|
| CAS Number | 446262-90-4 |
| Molecular Formula | C165H269N47O46 |
| Molecular Weight | 3647.19 g/mol |
| Peptide Sequence | Modified GHRH (1-29) with C-terminal DAC attachment |
| Purity (HPLC) | ≥98.0% |
| Appearance | White lyophilized solid |
| Solubility | Soluble in sterile water or bacteriostatic water |
Storage and Reconstitution
To maintain peptide integrity and stability, please adhere to standard laboratory handling guidelines:
- Lyophilized Form (Dry Powder): Store desiccated at -20°C (or below) upon receipt. While stable at room temperature for brief transit periods, long-term freezing is required to prevent degradation.
- Reconstitution: Reconstitute using bacteriostatic water or sterile water for injection. Introduce the diluent carefully and gently swirl the vial until dissolved. Do not shake vigorously, as this can fracture the peptide bonds.
- Liquid Storage (Reconstituted): Once reconstituted, the solution should be stored at 2°C to 8°C (refrigerated) and utilized within 14 to 30 days. For extended experimental timelines, aliquot the solution into individual vials and freeze at -20°C to avoid repeated freeze-thaw cycles.
Regulatory & Safety Disclaimer
NOTICE TO BUYER: By purchasing this product, you legally acknowledge and agree that it is strictly for Research Use Only (RUO). It is unequivocally prohibited to be used as a drug, food additive, cosmetic, or household chemical.
- Not for Human or Animal Use: This material has not been evaluated or approved by the FDA (or any other international regulatory agency) for therapeutic, diagnostic, or clinical use.
- Qualified Personnel: This product must be handled exclusively by qualified scientific professionals in a regulated laboratory setting, utilizing standard safety and sterile protocols.
- Liability: The purchaser assumes all risks and liabilities associated with the handling, storage, and experimental application of this product.
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